Anti–microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways
نویسندگان
چکیده
منابع مشابه
Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways.
MicroRNA-21 (miR-21) contributes to the pathogenesis of fibrogenic diseases in multiple organs, including the kidneys, potentially by silencing metabolic pathways that are critical for cellular ATP generation, ROS production, and inflammatory signaling. Here, we developed highly specific oligonucleotides that distribute to the kidney and inhibit miR-21 function when administered subcutaneously ...
متن کاملTracing ischemic memory by metabolic pathways: BMIPP and beyond
Myocardial ischemia (MI) resulting in infarction is an important cause of mortality and morbidity worldwide. Acute ischaemia rapidly impairs myocardial contractile function. Myocardial dysfunction persisting for several hours after transient non-lethal ischaemia, eventually resulting in full functional recovery is termed as myocardial stunning. Hibernation is now thought to be...
متن کاملOsteopontin deficiency ameliorates Alport pathology by preventing tubular metabolic deficits.
Alport syndrome is a rare hereditary renal disorder with no etiologic therapy. We found that osteopontin (OPN) is highly expressed in the renal tubules of the Alport mouse and plays a causative pathological role. OPN genetic deletion ameliorated albuminuria, hypertension, tubulointerstitial proliferation, renal apoptosis, and hearing and visual deficits in the Alport mouse. In Alport renal tubu...
متن کاملIdentifying Branched Metabolic Pathways by Merging Linear Metabolic Pathways
This paper presents a graph-based algorithm for identifying complex metabolic pathways in multi-genome scale metabolic data. These complex pathways are called branched pathways because they can arrive at a target compound through combinations of pathways that split compounds into smaller ones, work in parallel with many compounds, and join compounds into larger ones. While most previous work ha...
متن کاملPathological Features of Proteinuric Nephropathy Resembling Alport Syndrome
25 The renal biopsy tissue from a 9-month-old, male Pyrenean Mountain dog with 26 renal disorder and severe proteinuria was examined. Ultrastructural examination 27 revealed multilaminar splitting and fragmentation of the glomerular basement 28 membrane (GBM) and diffuse podocyte foot process effacement. 29 Immunofluorescent staining for α(IV) chains revealed presence of α5(IV) and 30 complete ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2014
ISSN: 0021-9738
DOI: 10.1172/jci75852